2 edition of Evidence that Pten loss induces mammary tumours by targeting stem/progenitor cells. found in the catalog.
Evidence that Pten loss induces mammary tumours by targeting stem/progenitor cells.
Rajwinder Singh Lehal
Written in English
Phosphatase and Tensin homolog deleted on chromosome 10 (Pten), an antagonist of Phosphotidylinositol-3 Kinase (PI3K) signaling, is one of the most commonly inactivated tumour suppressor genes in human cancers. However, its role in breast cancer is not well understood.Here I have used a conditional knock-out mouse model in which Pten was specifically disrupted in the mammary gland to study the effect of the PI3K/Pten pathway on the mammary stem cell compartment and tumour-initiating cells. The loss of Pten in mammary epithelium gave rise to mixed population tumours containing myoepithelial and luminal epithelial cells and lead to an expansion of stem cell population. PtenDeltaf/f mammary tumours exhibited nuclear accumulation of cyclin D2 and beta-catenin and contained keratin 6 positive cell population. Comparative analysis of Pten Deltaf/f mammary tumours suggested that like MMTV-Wnt1, loss of Pten in the mammary gland induces tumours by targeting the stem cell/early progenitor cell population.
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CONTENTS. vii. Overcoming Side Population Limitations, 80 Conclusions and Future Perspectives, 81 References, 82 5 Evidence for Cancer Stem Cells in Retinoblastoma. Cancer Stem Cells: Methods and Protocols Gianpaolo Papaccio, Vincenzo Desiderio (eds.) This detailed volume gathers a comprehensive collection of methods, protocols, and procedures used for the identification, characterization, and selection of cancer stem cells.
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, with dismal survival outcomes. Recently, cancer stem cells (CSCs) have been demonstrated to play a role in therapeutic resistance and are considered to be the most likely cause of cancer relapse. The identification of CSCs is an important step toward finding new and effective ways to treat GBM. Tenascin-C (TNC) protein has been Cited by: European Journal of Cancer Aims and Scope The European Journal of Cancer (EJC) is an international multidisciplinary oncology journal, which publishes original research, reviews, and editorial comments on basic and preclinical cancer research, translational oncology, clinical oncology – including medical oncology, paediatric oncology.
Pazopanib and sunitinib showed similar efficacy in a phase III clinical trial but pazopanib appears to have better tolerability among patients. Unlike pluripotent embryonic stem cells that are able to give rise to all cells of the body, these tissue-specific stem cells are multipotent they are restricted to producing cells found within the breast tissue. Support for Normal Murine Mammary Stem Cells The first evidence of a potential mammary stem cell was observed by Deome etal.
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Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland Article in Development (17) October with 22 Reads How we measure 'reads'. PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human cancers, while germline PTEN mutations cause inherited syndromes that lead to increased risk of tumors.
PTEN restrains tumorigenesis through different mechanisms ranging from phosphatase-dependent and independent Cited by: 5. CREB Signaling in Neural Stem/Progenitor Cells: Implications for a Role in Brain Tumors regions include the ventricular zones of both the lateral and third ventricles and the.
Studies of the embryonic mammary gland have also yielded evidence for the existence of a bipotent stem/progenitor cell population. 52 Importantly, and in contrast to the studies performed with Cited by: Transgenic Mice with a Mammary-Specific Expression of Oncogenes.
The primary objective to use conventional transgenic mice for breast cancer research is to overexpress the coding region of an oncogene (wild-type or mutant) or tumor-associated microRNA under the regulation of a mammary-specific by: 1.
The term ‘‘oxidative stress” refers to a cell’s state characterized by excessive production of reactive oxygen species (ROS) and oxidative stress is one of the most important regulatory mechanisms for stem, cancer, and cancer stem cells.
The concept of cancer stem cells arose from observations of similarities between the self-renewal mechanism of stem cells and that of cancer stem Cited by: Abstract. Here we review current literature on genetic and signaling pathway regulators of tumor initiating cells in prostate cancer.
While we emphasize the consequence of PTEN loss and PI3K/AKT activation in prostate cancer initiating cells, we also assess the importance of other signaling regulators, including RAS/MAPK, WNT/b-catenin, MYC, NKX and p53 on these antly, Cited by: 1.
These cells, termed cancer stem cells (CSCs) or tumor initiating cells, not only drive tumor initiation and growth but also mediate tumor metastasis and therapeutic resistance.
In this chapter, we summarize current advances in CSC research with a major focus on breast CSCs (BCSCs).Cited by: GBM. Primary GBM is the most common form of brain tumors  and is designated as World Health Organization (WHO) grade IV astrocytoma .Primary GBM is very aggressive and its initiation and recurrence is believed to be caused by GSCs which may be derived from mutated neural stem and precursor cells .Furthermore, in contrast to the origin of primary GBM, secondary GBM tumors Cited by: Cells expressing Keratin-6 and Sca1, molecular markers associated with mammary stem/progenitor cells are enriched in MMTV-Wnt-1 and MMTV-β-catenin transgenic mouse breast cancer models.
Interestingly, this population of cells does not increase when mammary tumors are induced by NeuT, H-Ras or PyMT, suggesting the specificity of Wnt in Cited by: In the era of precision medicine, the identification of new targets is a constant challenge to improve cancer therapy. Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer by: Ectopic Wnt‐1 expression has been shown to increase mammary stem and progenitor cells in pre‐neoplastic tissue suggesting Wnt‐1 may alter the epithelial hierarchy and MMTV‐Wnt‐1 tumors contain cells capable of multi‐lineage differentiation whereas MMTV‐Neu tumors are composed of luminal committed cells suggesting these tumors Cited by: Don S.
Dizon, MD, Assistant in Medicine, Medical Gynecologic Oncology, Massachusetts General Hospital, explains the relationship between PTEN mutations and mTOR inhibitors in endometrial cancer.
Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg med chem lett, Vol (15), pp.
The existence of stem cells in the adult mammary was suggested by classic transplantation studies, 93, 94 and the ability of a single cell to repopulate the mammary gland was inferred from retroviral tagging strategies, indicating that a single labeled cell could generate a mammary tree as a clonal outgrowth.
95 Later, flow-sorting with. BRCA1 has been shown to play a role in the regulation of mammary stem/progenitor cell fate and its inactivation results in the accumulation of progenitor cells, while Oct4 and Sox2, two decisive proteins in the maintenance of stemness, are activated by a complex of DNA repair proteins, which turned out to be necessary for the pluripotency of Cited by: 1.
INTRODUCTION OF PI3K/PTEN SIGNALING PATHWAY. The phosphatidylinositol 3-kinases (PI3Ks) in mammalian cells form a family that can be divided into three classes, class I, II, and III, based on their structure, substrate, distribution, mechanism of activation, and functions (Domin and Waterfield, ; Walker et al., ).Among these classes, class I PI3Ks are the best understood to play.
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In fact, emerging pieces of evidence suggest that Notch components are required for the survival of breast and intestinal cancer stem cells [, ].
Notch signaling has been associated with a number of hematopoietic and epithelial human tumors including colon, breast, lung, skin, cervical, prostate cancers, leukemia, and. This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilize.
This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging.Full text of "Stem Cells And Cancer Stem Cells" See other formats.When mice with breast cancer were treated with curcumin, the suppressive capacity of Treg cells was reduced and other T cells were able to destroy the tumor cells (Bhattacharyya ).
Apigenin Many studies have confirmed the cancer chemopreventive effects of apigenin (Sung ; Patel ).